The cervicaluterine cancer causes almost 250 000 death a year around the world and around 400 in cuba in spite of the efforts made by the public health ministry through the screening program. Molecular biology and cancer s genetics are useful tools in understanding carcinogenesis. Molecular aspects of human papillomavirus and cervical cancer. The cervix cancer is still the second cause of death due to malignant diseases among women, although theoretically, it is a preventable disease. Cancer incidence, mortality, and prevalence worldwide. Cellular functions are controlled by proteins, and because these proteins are encoded by dna organized into genes, molecular studies have shown that cancer is a paradigm. Oncogenic hpv dna is found in over 95% of invasive cervical cancers worldwide. However, the epidemiological studies have proved that a few women infected with hpv eventually progress to high risk intraepithelial lesions and in situ carcinoma. We use cookies to offer you a better experience, personalize content, tailor advertising, provide social media features, and better understand the use of our services.
Cervical cancer is a leading cause of cancer deaths in developing countries because of high hpv infection rates and lack of comprehensive cervical pap smear testing of susceptible women. Cancer is a group of diseases characterized by an autonomous proliferation of neoplastia cells which have a number of alterations, including mutations and genetic instability. Molecular biology and cancers genetics are useful tools in understanding carcinogenesis. With advances in molecular biology, diagnosis and classification have changed their treatment. Cervicouterine cancer screening with citology decrease incidence by more than 50%. The cause of this cancer is the human papilloma virus high risk, and requires a sensitive test to provide sufficient sensitivity and specificity for early detection and greater interval period when the results are negative. Molecular mechanisms of hpv mediated neoplastic progression. The six traits are to maintain proliferative signaling. This cytological diagnosis is carried out through the. Biologia molecular del vph tipo 16 y su asociacion al cancer cervico uterino. Human papillomavirus is the major etiological agent in the development of cervical cancer but not a sufficient cause. The american cancer society is a qualified 501c3 taxexempt organization. Hanahan and weinberg described the hallmarks or features of cancer, such as the cancer cells capacity for development and progression of clinically manifest cancer.
Prostate cancer has become one of the most frequently diagnosed tumors in men and is one of the leading causes of death in men over 50 years old. Despite significant research, the underlying mechanisms of progression from a lowgrade squamous intraepithelial lesion to high grade squamous intraepithelial lesion are yet to. Infeccion por vph y cancer cervicouterino medigraphic. Due to the development of molecular biology techniques.
In the pathogenesis of cervical carcinoma there are three major components, two of them related to the role of human papillomaviruses hpv. Biologia molecular del cancer y las nuevas herramientas en. The molecular genetics of cervical carcinoma british. Gutierrezxicotencatl and others published biologia molecular del cancer cervicouterino find, read and cite all the research.
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